Pronunciation: (u-spīur'),[key] —v.i.,-pired, -pir•ing. 1. to long, aim, or seek ambitiously; be eagerly desirous, esp. for something great or of high value (usually fol. by to, after, or an infinitive): to aspire after literary immortality; to aspire to be a doctor. 2. Archaic.to rise up; soar; mount; tower.