/ Dictionary / Index D Department of Commerce: Meaning and Definition of Find definitions for: Depart'ment of Com'merce Pronunciation: [key] the department of the U.S. federal government that promotes and administers domestic and foreign commerce. Abbr.: DOC Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Department of Agriculture Department of Defense Related Content Daily Word Quiz: effervescent Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language