Pronunciation: (hōp'lis),[key] —adj. 1. providing no hope; beyond optimism or hope; desperate: a hopeless case of cancer. 2. without hope; despairing: hopeless grief. 3. impossible to accomplish, solve, resolve, etc.: Balancing my budget is hopeless. 4. not able to learn or act, perform, or work as desired; inadequate for the purpose: As a bridge player, you're hopeless.