/ Dictionary / Index S San Luis Obispo: Meaning and Definition of Find definitions for: San Lu•is O•bis•po Pronunciation: (san l'is u-bis'pō), [key] a city in W California. 34,252. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. San Lorenzo San Luis Potosí Related Content Daily Word Quiz: illegible Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language