/ Dictionary / Index S Santa Cruz: Meaning and Definition of Find definitions for: San•ta Cruz Pronunciation: (san'tu krz' for 3 also Sp. sän'tä krs'), [key] a city on the coast of California. 41,483. an island in NW Santa Barbara Islands. a city in central Bolivia. 149,230. See(def. 1). Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Santa Coloma de Gramanet Santa Cruz de Tenerife Related Content Daily Word Quiz: loathe Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language