/ Dictionary / Index S Santa Fe Trail: Meaning and Definition of Find definitions for: San'ta Fe' Trail' Pronunciation: [key] an important trade route going between Independence, Missouri, and Santa Fe, New Mexico, used from about 1821 to 1880. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Santa Fe Springs Santa Gertrudis Related Content Daily Word Quiz: acerbity Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language