Pronunciation: (san'tu mu-rē'u; for 1, 2 also Sp. sän'tä mä-rē'ä; for 3 also Port. sän'tu mä-remacr;'ä),[key] 1. (italics) the flagship used by Columbus when he made his first voyage of discovery to America in 1492.
2. an active volcano in W Guatemala. 12,300 ft. (3750 m).
3. a city in S Brazil. 120,667.
4. a city in W California. 39,685.