/ Dictionary / Index S Santo Domingo: Meaning and Definition of Find definitions for: San•to Do•min•go Pronunciation: (san'tō du-ming'gō Sp. sän'tô &thslashô-mēng'gô), [key] Formerly,a city in and the capital of the Dominican Republic, on the S coast: first European settlement in America 1496. 980,000. a former name of a former name of Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Santo André santonica Related Content Daily Word Quiz: labyrinth Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language