/ Dictionary / Index S Santo Tomé de Guayana: Meaning and Definition of Find definitions for: San•to To•mé de Gua•ya•na Pronunciation: (sän"tô tô-me' e gwä-yä'nä), [key] a city in NE Venezuela, on the Orinoco River. 143,540. Also called Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Santos-Dumont Sanusi Related Content Daily Word Quiz: labyrinth Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language